Buy Cheap All-Natural Chicago Endocrine Health 13C & DIM Anti-Aging Herbal Supplements Vitamins
Why pick our Natural Endocrine Health 13C & DIM Herbal Supplement?
There are many options available today when choosing vitamins and anti-aging supplements. This means that you have to be careful as a consumer and make sure you choose a reliable manufacturer who only uses the highest quality ingredients. The Chicago Center For Anti-Aging has partnered with one of the most reputable manufacturers which helps ensure the quality of our private line of vitamins and anti-aging supplements. Quality is what should be the most important attribute you should look for to help make your decision, not cost. Look for quality you can trust.
Two-piece veggie capsule, size OO
Other Ingredients: Natural Vegetable Capsules. This products may contain one or more of the following: Calcium Silicate, Magnesium Stearate, Microcrystalline Cellulose, Silicon Dioxide and Stearic Acid.
This product is intended for those wanting the benefit of both preformed DIM as well as the precursor I3C for estrogen modulation and decreased risk of both breast and prostate cancers.
Indole-3-carbinol (I3C) is naturally occurring compound within numerous cruciferous vegetables (broccoli, cabbage etc.). After ingestions I3C converts to several different metabolites, one of which is diindolylmethane (DIM). Both of these compounds, as well as other I3C metabolites, have been shown to cause metabolic shifts and cellular activities that inhibit carcinogenesis; especially of breast and prostate cancers.1 General uses include improved phase I and phase II detoxification and antioxidant support.
In vitro and mechanisms: (2-10,13)
Several different mechanism have been attributed to I3C, DIM and other metabolites. Primary among them are:
• Change in Cytochrome P450 metabolism of estrogens to promote 2-hydroxyestrone in place of the more estrogenic (carcinogenic) 16-hydroxyestrogen.
• Direct effects on estrogen receptors which down regulate response
• Increased activation and expression of cancer suppressing molecules
• Down regulation of cancer promoting signaling molecules
• Women with SLE were given 375 mg/day of I3C for 3 months. 2/16 hydroxyestrone ratio shifted significantly upward.4
• Dose-range placebo controlled trial determined that 300 mg/day of I3C is optimal for shifting 2/16 hydroxyestrone levels.11,12
Numerous research papers show I3C and/or DIM to be inhibitory for prostate cancer cells and tissues.
By providing the stable DIM metabolite, considered to be one of the main functional metabolite, along with I3C (which will convert to DIM or other active metabolites) we ensure an active product. Currently, while most researchers consider DIM to be the main active metabolite, only I3C has been used in published clinical trials.
1 capsule per day or as recommended by your health care professional.
• As this product alters estrogen metabolism through the cytochrome P450 pathways, this product should not be consumed by women who are pregnant or who are trying to become pregnant, or women on oral contraceptives.
• Individuals on prescription medication which are metabolized via P450 enzymes may have reduced effectiveness of those drugs.
• Individuals on antacids or H2 blockers may limit the conversion of I3C if the stomach pH rises too much.
DIM vs I3C
There is much debate about whether it is better to use I3C or DIM or DIM that has been modified for increased absorption. Most published trials to date use oral I3C. DIM is more stable but has reduced absorption. Much talk has been made of Bio-Response DIM- an improved absorption form of DIM. In Rats give I3C and BioResponse DIM, the I3C was capable of inducing CYP1A1 enzymes, responsible for the 2/16 ratio, while the BioResponse DIM was not.
Do not consume this product if you are pregnant or nursing
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1. Brignall MS Prevention and treatment of cancer with indole-3-carbinol. Altern Med Rev. 2001 Dec;6(6):580-9
2. Auborn KJ, Fan S et al. Indole-3-carbinol is a negative regulator of estrogen. J Nutr. 2003 Jul;133(7 Suppl):2470S-2475S.
3. Ashok BT Abrogation of estrogen-mediated cellular and biochemical effects by indole-3-carbinol. Nutr Cancer. 2001;41(1-2):180-7.
4. McAlindon TE et al. Indole-3-carbinol in women with SLE: effect on estrogen metabolism and disease activity. Lupus. 2001;10(11):779-83.
5. Meng Q et al. Indole-3-carbinol is a negative regulator of estrogen receptor-alpha signaling in human tumor cells. J Nutr. 2000 Dec;130(12):2927-31
6. Yuan F et al. Anti-estrogenic activities of indole-3-carbinol in cervical cells: implication for prevention of cervical cancer. Anticancer Res. 1999 May-Jun;19(3A):1673-80.
7. Meng Q, Qi M et al. Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes. J Mol Med. 2000;78(3):155-65.
8. Lee IJ, Han F, Baek J, Hisatsune A, Kim KC. Inhibition of MUC1 expression by indole-3-carbinol. Int J Cancer. 2004 May 10;109(6):810-6
9. Brandi G et al. A new indole-3-carbinol tetrameric derivative inhibits cyclin-dependent kinase 6 expression, and induces G1 cell cycle arrest in both estrogen-dependent and estrogen-independent breast cancer cell lines. Cancer Res. 2003 Jul 15;63(14):4028-36.
10. Hong C, Firestone GL, Bjeldanes LF. Bcl-2 family-mediated apoptotic effects of 3,3’-diindolylmethane (DIM) in human breast cancer cells. Biochem Pharmacol. 2002 Mar 15;63(6):1085-97
11. Wong GY, Bradlow L et al. Dose-ranging study of indole-3-carbinol for breast cancer prevention. J Cell Biochem Suppl. 1997;28-29:111-6.
12. Bradlow HL, Michnovicz JJ et al. Long-term responses of women to indole-3-carbinol or a high fiber diet. Cancer Epidemiol Biomarkers Prev. 1994 Oct-Nov;3(7):591-5.
13. Firestone GL, Bjeldanes LF. Indole-3-carbinol and 3-3’-diindolylmethane antiproliferative signaling pathways control cell-cycle gene transcription in human breast cancer cells by regulating promoter-Sp1 transcription factor interactions. J Nutr. 2003 Jul;133(7 Suppl):2448S-2455S.
14. Zhang J et al. Indole-3-carbinol induces a G1 cell cycle arrest and inhibits prostate-specific antigen production in human LNCaP prostate carcinoma cells. Cancer. 2003 Dec 1;98(11):2511-20.
15. Nachshon-Kedmi M, Yannai S, Haj A, Fares FA. Indole-3-carbinol and 3,3’-diindolylmethane induce apoptosis in human prostate cancer cells. Food Chem Toxicol. 2003 Jun;41(6):745-52.
16. Frydoonfar HR, McGrath DR, Spigelman AD. The effect of indole-3-carbinol and sulforaphane on a prostate cancer cell line. ANZ J Surg. 2003 Mar;73(3):154-6.
17. Chinni SR, Sarkar FH. Akt inactivation is a key event in indole-3-carbinol-induced apoptosis in PC-3 cells. Clin Cancer Res. 2002 Apr;8(4):1228-36.
18. Chinni SR, Li Y, Upadhyay S, Koppolu PK, Sarkar FH. Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells. Oncogene. 2001 24;20(23) :29236.
19. Leibelt DA et al. Evaluation of chronic dietary exposure to indole-3-carbinol and absorption-enhanced 3,3’-diindolylmethane in sprague-dawley rats. Toxicol Sci. 2003 Jul;74(1):10-21. Epub 2003 May 02.
20. Hanausek M, Walaszek Z, Slaga TJ. Detoxifying cancer causing agents to prevent cancer. Integr Cancer Ther. 2003 Jun;2(2):139-44.
21. Singh J, Gupta KP. Calcium glucarate prevents tumor formation in mouse skin. Biomed Environ Sci. 2003 Mar;16(1):9-16.
22. Review. Calcium-D-glucarate. Altern Med Rev. 2002 Aug;7(4):336-9. (Free online)
23. Walaszek Z, Szemraj J et al. Metabolism, uptake, and excretion of a D-glucaric acid salt and its potential use in cancer prevention. Cancer Detect Prev. 1997;21(2):178-90.
** Information for health care professionals only.
** These statements have not been evaluated by the FDA. This product is not intended to treat, diagnose, prevent, or cure any disease. Consult a physician before taking. Should you experience any serious physical side effects from taking these nutritional supplements, discontinue and call your doctor immediately.